Design and engineering of deimmunized biotherapeutics
نویسندگان
چکیده
منابع مشابه
architecture and engineering of nanoscale sculptured thin films and determination of their properties
چکیده ندارد.
15 صفحه اولParticle engineering for inhalation formulation and delivery of biotherapeutics
Introduction Inhalation as a drug delivery route has been in clinical practice for more than 50 years, with small molecules for the treatment of asthma/COPD capturing the ma jority market share of inhalation products. Since that time, protein therapeutics or biotherapeutics have emerged as a significant class of drugs in clinical development and on the market. Delivery of biotherapeutics direct...
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Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic design is therefore to identify mutants of the protein sequence that minimize immunogenicity in a target population whilst retaining pharmaceutical activity and protein function. Current approaches are moderately suc...
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A brief background to the development of the rock engineering design process is given, showing that since the development of the science of mathematics, deterministic methods have been used to perform various calculations. The variability of rock properties and support characteristics have always been known. However, they were not explicitly used in design but compensated for by the use of a sa...
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اتانول کاربردهای متنوعی در صنایع لاستیک سازی، رنگسازی، حلالها ومکمل سوخت خودرو دارد. اتانول برخلاف نفت از جمله مواد تجدیدپذیر محسوب می شود که مشکلات زیست محیطی و آلودگی نیز ایجاد نمی کند. استفاده از اتانول به عنوان مکمل سوختخودروها از جمله مهمترین مصارف صنعتی این ماده بشمار می رود. با توجه به این موضوع تحقیق و توسعه در زمینه تولید اتانول با درجه خلوص بالا در سطح جهان، و نه تنها در کشور های پیشر...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2016
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2016.06.003